The PRP shot can also increase sexual performance and penis size in men who do not have any issues. This shot does not have any reported side effects or allergic reactions because you are using PRP from your own blood. Our physicians first administer a penile nerve block and then apply topical numbing cream so that the procedure is nearly pain free. The procedure take about 30 minutes and patients can engage in sexual activity that day. Patients typically see results in 2-3 weeks and the beneficial effects can last up to 18 months. Regular use of a penis pump can enhance the effects of the PRP shot.